Metabolites Profiling and Fingerprinting of the Ethanolic Extract of Zingiber zerumbet (L.) Roscoe ex Sm.
DOI:
https://doi.org/10.37134/jsml.vol10.1.10.2022Keywords:
metabolites profiling, fingerprinting, extract, Zingiber zerumbet, bitter gingerAbstract
Zingiber zerumbet (L.) Roscoe ex Sm. is a herbaceous medicinal plant from the Zingiberaceae family. Previous studies have mainly focused on the essential oils of the plant with little attention to its secondary metabolites. LCMS-Orbitrap is used to analyze ethanolic extract of Z. zerumbet rhizome. Dereplication is a technique applied to identify chemical constituents based on their accurate mass and comparison with custom databases, Dictionary of Natural Products (DNP), and literature using an operating system named MZmine 2.53. In this study, we have identified chemical constituents related to several classes, including flavonoids, terpenoids, diarylheptanoids, terpenes, phenolic compounds, and fatty acids. Our results provide useful information for further isolation and identification of other unknown compounds and mass spectroscopy-based metabolite profiling of Zingiber species.
Downloads
References
Erb, M., & Kliebenstein, D.J. (2020). Plant secondary metabolites as defenses, regulators, and primary metabolites: the blurred functional trichotomy1. Plant Physiology, 184(1), 39-52.
Koga, A.Y., Beltrame, F.L., & Pereira, A.V. (2016). Several aspects of Zingiber zerumbet: a review. Revista Brasileira de Farmacognosia, 26(3), 385-391.
Moreira da Silva, T., Pinheiro, C.D., Puccinelli Orlandi, P., Pinheiro, C.C & Pontes, G.S. (2018). Zerumbone from Zingiber zerumbet (L.) smith: a potential prophylactic and therapeutic agent against the cariogenic bacterium Streptococcus mutans. BMC Complementary Medicine and Therapies, 15, 301-310.
Prakash, R.O., Rabinarayan, A., & Kumar, M.S. (2011). Zingiber zerumbet (L.) Sm., a reservoir plant for therapeutic uses: a review. International Journal of Pharma World Research, 2(2), 1-23.
Rajkumari, S., & Sanatombi, K. (2018). In vitro production of some important secondary metabolites from Zingiber species. In Biotechnological Approaches for Medicinal and Aromatic Plants: Conservation, Genetic Improvement, and Utilization, p. 213-233.
Sharifi-Rad, M., Varoni, E.M., Salehi, B., Sharifi-Rad, J., Matthews, K.R., Ayatollahi, S.A., Kobarfard, F., Ibrahim, S.A., Mnayer, D., Zakaria, Z.A., Sharifi-Rad, M., Yousaf, Z., Iriti, M., Basile, A., & Rigano, D. (2017). Plants of the genus Zingiber as a source of bioactive phytochemicals: from tradition to pharmacy. Molecules, 22(12), 1-20.
Shen, B. (2015). A new golden age of natural products drug discovery. In Cell, 163(6), 1297-1300.
Singh, C. B., Nongalleima, K., Brojendrosingh, S., Ningombam, S., Lokendrajit, N., & Singh, L. W. (2012). Biological and chemical properties of Zingiber zerumbet Smith: A review. Phytochemistry Reviews, 11(1), 113-125.
