Pharmacological Activities of the Genus Globimetula and Scurrula


  • Kamal Ja’afar Muhammad Chemistry Advanced Research Centre, Sheda Science and Technology Complex, Garki, Abuja-Nigeria



Loranthaceae, phytochemicals, alkaloids, triterpenes, flavonoids


This article aims to deliver updates on the pharmacological activities of Globimetula and Scurrula species and their usage as ethnomedicine worldwide. About 13 species of Globimetula and 10 species of Scurrula are spread in Africa and Asia respectively. There is a need to establish the pharmacological properties of the plant extracts and isolated compounds from these species. Research on the biological activities of Globimetula and Scurrula species showed considerable disease-related enzyme (tyrosinase) inhibition as well as antioxidant, anti-inflammatory, antimicrobial, anticonvulsant, central nervous system depressant, and cytotoxic activities. This review also affords important information for the future growth of isolated compounds from Globimetula and Scurrula species.


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Adesina SK, Illoh CH, Imoh IJ, Jacobs EI. (2013). African mistletoes (Loranthaceae); ethnopharmacology, chemistry and medicinal values: an update. African Journal of Traditional, Complementary and Alternative Medicines, 10(4), 161-170.

Adewumi AAJ, Aina VO, Alhassan S, Adebayo FI. (2011). Antibacterial activity of Globimetulla browni (Mistletoe) leaf extract against four clinical bacterial isolates. Journal of Pharmaceuticals Allied Sciences, 8(3), 1355-1361.

Aditiyarini D, Restiani R, Evieyana E. (2022). Profiling secondary metabolites and antioxidant activity of tea mistletoe leaves (Scurrula artopurpurea (Bl.) Danser in Nglinggo, Kulon Progo, Yogyakarta. Jurnal Ilmiah Biologi, 10(2), 196-205.

Afolabi CA, Jonhson AO, Kayode K, Joan O, Mary TO. (2016). Antioxidant activity and protective effects of cocoa and kola nut mistletoe (Globimetula cupulata) against ischemia/reperfusion injury in langendoff-perfused rat hearts. Journal of Food and Drug Analysis, 24, 417-426.

Alhassan AM, Lawal NB, Danladi S. (2023). Analgesic and anti-inflammatory studies of the methanol extract of Globimetula braunii (Loranthaceae) growing on Terminalia catappa Linn (Combretaceae). Journal of Pharmacy and Bioresources, 20(2), 1-13.

Athiroh N, Wahyuningsih D. (2017). Study of superoxide dismutase and malondialdehyde concentrations in mice after administration of methanolic extract of Scurrula atropurpurea (Bl.). Jurnal Kedokteran Hewan, 11(1), 19-22.

Ayoola MD, Oriola AO, Faloye KO, Aladesanmi AJ. (2020). Two antihyperglycaemic compounds from Globimetula braunii (Engl.) Van Tiegh (Loranthaceae). GSC Biological and Pharmaceutical Sciences, 11(1), 46-54

Barlow BA. (1991). Conspectus of the genera Scurrula L. and Taxillus Tieghem (Loranthaceae) in the Malesian region. Blumea, 36, 63-85.

Bruno NL, Joel TA, Jean RC, Makoah NA, Flora N, Gabriele P, Beate N, Hans GS, Catherin V, Silvere N, Norbert S. (2015). Two 2,6-dioxabicyclo[3.3.1]nonan-3-ones from Phragmanthera capitata (Spreng.) Balle (Loranthaceae). Helvetica Chimica Acta, 98, 945-952.

Danladi S, Musa AM, Yaro AH. (2019). Central nervous system depressant activity of ethanol leaf extract of Globimetula braunii (Engler) (Loranthaceae) growing on Terminalia capatta L. (Combretaceae). Bayero Journal of Pure and Applied Sciences, 12(1), 321-327.

Danladi S, Sule MI, Musa AM, Yaro AH. (2021). Central nervous system depressant activity of fractions of Globimetula braunii Engl. (Loranthaceae) growing on Terminalia catappa L. (Combretaceae) and isolation of lupeol. Journal of Pharmacy and Bioresources, 18(3), 196-206.

Danladi S, Alhassan AM, Sule MI, Mushamma MA, Yaro AH. (2022). Phytochemical Constituents and Pharmacological Activities of Globimetula braunii (Loranthaceae): A Review. Tropical Journal of Natural Product Research, 6(9), 1372-1377.

David OE. (2009). Biochemical changes in wistar rats on oral doses of aqueous extracts of the leaves of Globimetula cupulata (DC) van Tieghem. Pharmacologyonline, 3, 275-282.

Ebadi M. (2007). Pharmacodynamic basis of herbal medicine, 2nd Ed., Taylor and Francis Group: New York.

Erukainure LO, Joseph AA, Adeniyi SA, Rabiat UE, Michael AF. (2011). Antilipemic and hypocholesteremic activities of Globimetula braunii in rats. Experimental of Toxicologic Pathology, 63, 657-661.

Faboro EO, Olawuni IJ, Bolajoko A, Akinpelu BA, Oyedapo OO, Iwalewa EO, Obafem CA. (2020). Investigation on in vitro evaluation of antioxidant and anti-inflammatory properties of methanol and dichloromethane extracts of leaf of Globimetula oreophila. Current Research and Development in Chemistry, 4, 143-161.

Faboro EO, Omisore NO, Alabi BA, Iwalewa EO, Obafemi CA. (2022). In vivo assessment of analgesic and anti-inflammatory activities of methanol extract of the leaves of Globimetula Oreophila. Adeleke University Journal of Science, 1(2), 555-566.

Francoise LD, Sophie T, Didier F, Joel B. (2002). Flavonols from Scurrula ferruginea Danser (Loranthaceae). Verlag der Zeitschrift für Naturforschung Tübingen, 7, 1092-1095.

Fred-Jaiyesimi A, Onabanjo T, Ademuyiwa O. (2008). Phytochemical and laxative studies of Globimetula braunii (Engle) van Tiegh growing on Cola acuminata (Schott & Endl). African Journal of Traditional, Complementary and Alternative Medicine, 5(4), 419-420.

Fred-Jaiyesimi A, Onabanjo T, Jaiyesimi A. (2008). Biochemical and toxicological effects of Globimetula braunii (Loranthaceae) leaf. African Journal of Traditional, Complementary and Alternative Medicine, 10, 83-89.

Hardiyanti R, Marpaung L. (2018). Phytochemical and toxicity test of n-hexan extracts of Dukus mistletoe leaf (Dendrophtoe pentandra) and (Scurrula ferruginea) collected from Medan, Indonesia. AIP Conference Proceedings, 030015.

Hasan SM, Ahmed IM, Mondal S, Uddin SJ, Masud MM, Sadhu SK, Ishibashi M. (2006). Antioxidant, antinociceptive activity and general toxicity study of Dendrophthoe falcata and isolation of quercitrin as the major component. Oriental Pharmacy and Experimental Medicine, 6(4), 355-360.

Hernayanti LS, Taufiq HKK. (2019). Detoxification of Cadmium on the levels of urea and creatinine on rattus Norvegicus with Tea Mistletoe (Scurrula Atropurpurea). AIP Conference Proceedings 2094, 020026.

Hong X, Ajat M, Fakurazi S, Noor AM, Ismail IS. (2021). Anti-inflammatory evaluation of Scurrula ferruginea (jack) danser parasitizing on Tecoma stans (L.) H.B.K. in LPS/IFN-γ-induced RAW 264.7 macrophages. Journal of Ethnopharmacology, 265, 113647.

Hong X, Isa NM, Fakurazi S, Ismail IS. (2019). Phytochemical and anti-inflammatory properties of Scurrula ferruginea (Jack) Danser parasitising on three different host plants elucidated by NMR-based metabolomics. Phytochemical Analysis, 31(1), 15-27.

Inuwa HM, Aina VO, Ibrahim S, Ameh DA. (2012). Phytochemical screening and antibacterial activity of Globimetulla browni extracts during dry season. British Journal of Pharmacology and Toxicology, 3(1), 4-6.

Justine VT, Musatafa M, Kankara SS, Go R. (2019). Effect of drying methods and extraction solvents on phenolic antioxidants and antioxidant activity of Scurrula ferruginea (Jack) Danser (Loranthaceae) leaf extracts. Sains Malaysiana, 48(7), 1383-1393.

Ja’afar KM, Shajarahtunnur J, Norazah B. (2017). Antioxidant activity of leaf extracts of Globimetula braunii (Engler) van tiegh parasitizing on Piliostigma thonningii and Parkia biglobosa. Jurnal Teknologi, 79, 43-47.

Ja’afar KM, Shajarahtunnur J, Norazah B, Mohd BB, Satyajit DS, Keith JF, Mathias OS. (2017). Lactones and flavonoids from the leaves of Globimetula braunii. Natural Product Communication, 12, 1455-1458.

Kazuyoshi O, Hendig W, Mutsuko M, Masahiro I, Made SP, Partomuan S, Hirotaka S. (2003). Indonesian Medicinal Plants. XXV. Cancer cell invasion inhibitory effects of chemical constituents in the parasitic plant Scurrula atropurpurea (Loranthaceae). Chemical Pharmaceutical Bulletin, 51(3), 343-345.

Kumar S, Shukla YN, Lavania UC, Sharma A, Singh AK. (1997). Medicinal and aromatic plants: prospects for India. Journal of Medicinal Aromatic Plant Science, 19, 361-36.

Laldingngheta J, Malsawmzuala L, Lalhlenmawia H. (2019). Evaluation of the anti-diabetic activity of ethanol extract of leaves of Scurrula parasitica in streptozotocin-induced diabetic rats. Journal of Pharmacognosy and Phytochemistry, 8(3), 2206-2212.

Lim YC, Rajabalaya R, Shirley HFL, Tennakoon KU, Quang-Vuong L, Idris A, Zulkipli IN, Keasberry N, David SR. (2016). Parasitic mistletoes of the genera Scurrula and Viscum: from bench to bedside. Molecules, 21, 1048.

Lin J, Lin Y. (1999). Flavonoids from the leaves of Loranthus kaoi (Chao). Kiu. Journal of Food Drug Analysis, 7(3), 185-190.

Mallavadhani UV, Narasimhan K, Sudhakar AVS, Mahapatra A, Li W, van Breemen RB. (2006). Three new pentacyclic triterpenes and some flavonoids from the fruits of an Indian Ayurvedic plant Dendrophthoe falcata and their estrogen receptor binding activity. Chemical and Pharmaceutical bulletin, 54(5), 740-744.

Marvibaigi M, Amini N, Supriyanto E, Abdul Majid FA, Jaganathan SK, Jamil S. (2016). Antioxidant activity and ros-dependent apoptotic effect of Scurrula ferruginea (Jack) Danser methanol extract in human breast cancer cell MDA-MB-231. PlosOne, 11(7), 0158942.

Mkounga P, Maza DHL, Ouahouo WBM, Tyon NL, Hayato I, Hiroshi N, Nkengfack AE. (2016). New lupan-type triterpenoids. Zeitschrift fur Naturforschung, 10, 0215-0235.

Mohsen M, Neda A, Eko S, Shajarahtunnur J, Fadzilah AA, Shahpour K. (2014). Total phenolic content, antioxidant and antibacterial properties of Scurrula ferruginea extracts. Jurnal Teknologi, 70(5), 65-72.

Mohsen, M., Neda, A., Eko, S., Fadzilah, A.A., Saravana, K.J., Shajarahtunnur, J., Javad, H. A. (2016). Rozita, N. Antioxidant activity and ROS-dependent apoptotic effect of Scurrula ferruginea (Jack) Danser methanol extract in human breast cancer Cell MDA-MB-231. PlosOne, 11(7), 1-5.

Muhammad KJ, Jamil S, Basar N, Magaji MG. (2019). Anticonvulsant studies on the isolated compounds from the leaves of Scurrula parasitica L (Loranthaceae). Malaysian Journal of Fundamental and Applied Sciences, 15, 806-810.

Muhammad KJ, Jamil S, Basar N. (2019). Phytochemical study and biological activities of Scurrula parasitica L. (Loranthaceae) leaves. Journal of Research in Pharmacy, 23, 522-531.

Muhammad KJ, Jamil S, Basar N, Sarker SD, Mohammed MG. (2020). Globrauneine A-F: six new triterpenoid esters from the leaves of Globimetula braunii. Natural Product Research, 34, 2746-2753.

Muhammad KJ, Jamil S, Basar N, Arriffin NM, Idris MT, Jibril S, Akanji FT. (2022). Antioxidant, antimicrobial, and antityrosinase activities of phytochemicals from the leaves of Globimetula braunii (Engler) van Tiegh (Loranthaceae). Bulletin of the Chemical Society of Ethiopia, 36, 387-397.

Musa MA, Abdullahi IM, Kamal MJ, Magaji GM. (2014). Phytochemical screening and anticonvulsant studies of ethyl acetate fraction of Globimetula braunii on laboratory animals. Asian Pacific Journal of Tropical Biomedicine, 4(4), 285-289.

Mustarichie R, Runadi D, Ramdhani D. (2017). The antioxidant activity and phytochemical screening of ethanol extract, fractions of water, ethyl acetate, and n-hexane from mistletoe tea (Scurrula atropurpurea Bl. Dans). Asian Journal of Pharmaceutical and Clinical Research, 10(2), 343-347.

Newman DJ, Cragg GM, Snader KM. (2000). The influence of natural products upon drug discovery. Natural Products Reports, 17, 215-234.

Newman DJ, Cragg GM, Snader KM. (2003). Natural products as sources of new drugs over the period 1981-2002. Journal of Natural Products, 66, 1022-1037.

Nilesh M, Parag J, Manish K, Senthil KKL, Vaidhyalingam V. (2013). Anti-nociceptive potential of Scurrula parasitica: An unexploited parasitic plant. Journal of Pharmacology, 3(1), 4-8.

Njoya EM, Maza HLD, Mkounga P, Koert U, Nkengfack AE, McGaw LJ. (2020). Selective cytotoxic activity of isolated compounds from Globimetula dinklagei and Phragmanthera capitata (Loranthaceae). Zeitschrift fur Naturforschung, 75(5-6), 135-144.

Nour A, Nur P, Djanggan S, Aris MW. (2014). Antioxidative and blood pressure-lowering effects of Scurrula atropurpurea on deoxycorticosterone acetateesalt hypertensive rats. Biomarkers Genome Medicine, 6, 32-36.

Nour A, Nur P, Djanggan S, Aris MW. (2014). Effect of Scurrula atropurpurea on nitric oxide, endothelial damage, and endothelial progenitor cells of DOCA-salt hypertensive rats. Iranian journal of Basic Medical Sciences, 17, 622-625.

Oboh IE, Nworgu ZAM. (2008). Oxytocic properties of the aqueous extract of Globimetulla braunii (Loranthaceae). Pakistan Journal of Pharmaceutical Science, 21(4), 356-360.

Ogbulie JN, Ogueke CC, Okorondu S. (2004). Antibacterial properties of A. cordifola, M. flurum, U. chaeme, B. pinnatum, C. albidem and A cilata on some hospital isolates. Nigerian Journal Microbiology, 18(2), 249-255.

Ojewole JAO, Adewole SO. (2007). Hypoglycemic and hypotensive effects of Globimetula cupulata (DC) Van Tieghem (Loranthaceae) aqueous leaf extract. Cardiovasc. South African Journal Botany, 18, 1, 9-15.

Okpuzor J, Kareem G. (2009). Lipid lowering Activity of Globimetula braunii. Research Journal of Medicinal Plant, 3(2), 45-51.

Okpuzor J, Ogbunugafor HA, Kareem GK. (2009). Hepatic and hematologic effects of fractions of Globimetula braunii in normal albino rats. Excli Journal. 8, 182-189.

Okpuzor J, Ogbunugafor HA, Kareem GK. (2009). Antioxidative properties of ethyl acetate fraction of Globimetula braunii in normal albino rats. Journal Biological Sciences, 9(5), 470-475.

Olanlokun JO, Ekundayo MT, Ebenezer O, Koorba NA, Olorunsogo OO. (2021). Antimalarial and erythrocyte membrane stability properties of Globimetula braunii (Engle Van Tiegh) growing on Cocoa in Plasmodium berghei-Infected Mice. Infection and Drug Resistance, 14, 3795-3808.

Olanlokun JO, Ekundayo MT, Koorbanally NA, Olorunsogo OO. (2022). Hexane fraction of Globimetula braunii induces mitochondria-mediated apoptosis in Plasmodium berghei-infected mice. Toxicology Reports, 9, 769-777.

Okpanachi GO, Oyi AR, Musa H, Abdulsamad A, Emenike AV, Sule YZ. (2020). Assessment of physicochemical properties of Globimetula braunii (Loranthaceae) leaf extracts. Journal of Science and Practice of Pharmacy, 7(1), 344-354.

Oriola AO, Aladesanmi AJ, Idowu TO, Akinwumi FO, Obuotor EM, Idowu T, Oyedeji AO. (2021). Ursane-type triterpenes, phenolics and phenolic derivatives from Globimetula braunii leaf. Molecules, 26, 6528.

Osungunna O, Osungunna MO, Abimbola Y. (2013). Phytochemical and antimicrobial screening of Globimetulla oreophila (olive) van Tiege and Phragmenthera capitate (Spreng) Balle. International Journal of Green Pharmacy, 7, 127-130.

Phillipson JD. (2001). Phytochemistry and medicinal plants. Phytochemistry, 56, 237-243.

Pieroni A, Price LL, Vandebroek I. (2005). Welcome to journal of ethnobiology and ethnomedicine. Journal of Ethnobiology and Ethnomedicine, 1, 1.

Puneetha GK, Amruthesh .N. (2016). Phytochemical screening and in vitro evaluation of antioxidant activity of various extracts of Scurrula parasitica. International Journal of Pharmaceutical and Biological Sciences, 6(1), 77-86.

Quan-Yu L, Fei W, Lei Z, Jie-Ming X, Li AP, Yong-Hong ZA. (2015). Hydroxylated lupeol-based triterpenoid ester isolated from the Scurrula parasitica Parasitic on Nerium indicum. Helvetica Chimica Acta, 98, 627-632.

Quan-Yu L, Fei W, Yong-Hong Z, Feng NI. (2016). Chemical constituents of Scurrula paracitica. China Journal of Chinese Material Medica, 41(21), 3956-3561.

Ramawat KG. (2004). Biotechnology of medicinal plants: vitalizer and therapeutic. Science Publishers Inc., New Hampshire.

Sembiring HB, Barus T, Marpaung L, Simanjuntak P. (2015). Antioxidant and Antibacterial Activity of Some Leaves Extracts (Methanol, Ethyl Acetate and N-Hexane) of Scurrula fusca G.Don. International Journal of PharmTech Research, 8(9), 24-30.

Sudiwati N, Nurseta T, Aulannia AMA, Ali M. (2015). In-vitro and in-silico anticancer activity of parasitic tea plant Scurrula atropurpurea (Blume) against cervical cancer. Sphinx Knowledge House, 8(7), 12-18.

Takashi I, Etsuji T, Hendig W, Kazuyoshi O, Hirotaka S. (2001). A complex of perseitol and K+ ion from Scurrula fusca (Loranthaceae). Tetrahedron Letters, 42, 6887-6889.

The Plant List, a working list of all known plant species. (2015). Version 1, released in January 1, 2010.

Tilney P, Lubke R. (1974). A chemotaxonomic study of twelve species of the family Loranthaceae. South African Journal Botany, 40, 315-322.

Tizhe TD, Alonge SO, Aliyu RE. (2015). Antibacterial activity of Globimetula braunii sourced from five different host trees in Samaru, Zaria, Nigeria. International Journal of Current Science, 18, 117-123.

Xiao YJ, Chen YZ, Chen BH, Chen JH, Lin ZX, Fan YL. (2008). Study on cytotoxic activities on human leukemia cell line HL-60 by flavonoids extracts of Scurrula parasitica from four different host trees. China Journal of Chinese Material Medica, 33(4), 427-432.

Yang L, Yan-Li Z, Yong-Ping Y, Xiao-Li L. (2011). Chemical constituents of Viscum album var. meridianum. Biochemical Systematic and Ecology, 39, 849-852.

Young-Kyoon K, Young SK, Sang UC, Shi YR. (2004). Isolation of flavonol rhamnosides from Loranthus tanakae and cytotoxic effect of them on human tumor cell lines. Archives of Pharmacal Research, 27(1), 44-47.




How to Cite

Muhammad, K. J. (2024). Pharmacological Activities of the Genus Globimetula and Scurrula. Journal of Science and Mathematics Letters, 12(1), 58–71.