Isolation of Alkaloids from Artabotrys suaveolens and Their Cytotoxic Activity

Authors

  • Saripah Salbiah Syed Abdul Azziz
  • Mat Ropi Mukhtar
  • A. Hamid A. Hadi
  • Khalijah Awang
  • Faridahanim Mohd Jaafar
  • Humera Naz
  • Norhadiani Ismail
  • Hiroshi Morita

Keywords:

Artabotrys suaveolens, Annonaceae, alkaloids, cytotoxicity, phytochemical investigation

Abstract

A phytochemical investigation on the stem bark of Artabotrys suaveolens has led to the isolation of an azaanthraquinone, cleistopholine (1) a dioxoaporphine alkaloid, artabotrine (2) and a benzylisoquinoline alkaloid, reticuline (3) The compounds were isolated using various chromatographic methods. The structures were mainly determined by spectroscopic methods such as 1H and 13C NMR, mass spectrometry and also by comparison with previous data. The compounds (1-3) have been isolated from others Atrabotrys species but here we are reporting for the first time from Artabotrys suaveolens. Meanwhile, artabotrine (2) showed a moderate cytotoxicity against human cancer cell lines, HL60, HCT116, RPMI8226 and MCF 7.

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Author Biographies

Saripah Salbiah Syed Abdul Azziz

Department of Chemistry, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia

Mat Ropi Mukhtar

Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia

A. Hamid A. Hadi

Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia

Khalijah Awang

Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia

Faridahanim Mohd Jaafar

Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA,
Kampus Puncak Alam, Bandar Puncak Alam 42300 Selangor

Humera Naz

Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA,
Kampus Puncak Alam, Bandar Puncak Alam 42300 Selangor

Norhadiani Ismail

Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA,
Kampus Puncak Alam, Bandar Puncak Alam 42300 Selangor.

Hiroshi Morita

Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan

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Published

2013-12-01

How to Cite

Syed Abdul Azziz, S. S., Mukhtar, M. R., A. Hadi, A. H., Awang, K., Mohd Jaafar, F., Naz, H., Ismail, N., & Morita, H. (2013). Isolation of Alkaloids from Artabotrys suaveolens and Their Cytotoxic Activity. Journal of Science and Mathematics Letters, 5(1), 19–27. Retrieved from https://ojs.upsi.edu.my/index.php/JSML/article/view/344