Mechanochemical Synthesis and Potentiation of the Antimicrobial Activity of 4-[3-(4-methoxyphenyl)-allylideneamino]-1,5-dimethyl-2-phenylpyrazol-3-one by Metal Chelation


  • Onyinye Chinelo Aguzue Sheda Science and Technology Complex, Abuja, Nigeria
  • Adebiyi Adedayo Sheda Science and Technology Complex, Abuja, Nigeria
  • Oviawe Amowie Phillip Department of Chemistry, University of Benin, Nigeria



mechanochemical; methoxycinnamaldehyde, 4-[3-(4-methoxyphenyl)-allylideneamino]-1,5-dimethyl-2-phenylpyrazol-3-one, 4-aminioantipyrine


A Schiff base ligand, 4-[3-(4-methoxyphenyl)-allylideneamino]-1,5-dimethyl-2-phenylpyrazol-3-one has been synthesized by the condensation of Methoxycinnamaldehyde and 4-aminoantipyrine. Its divalent metal complexes of Co, Ni, and Cu were also synthesized using the mechanochemical solvent-free method. The ligand and the complexes were characterized by FTIR, UV/visible, 1H NMR, 13C NMR, and GC-MS. The ligand behaved as a bidentate donor by using its carbonyl and azomethine N as binding sites for the metals. The ligand showed low activity against some microbes but the complexes were remarkably active against the fungi species.


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How to Cite

Aguzue, O. C., Adedayo, A., & Phillip, O. A. (2020). Mechanochemical Synthesis and Potentiation of the Antimicrobial Activity of 4-[3-(4-methoxyphenyl)-allylideneamino]-1,5-dimethyl-2-phenylpyrazol-3-one by Metal Chelation. Journal of Science and Mathematics Letters, 8(2), 15–21.

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